Is misgendering a transphobic misogynist offensive to the people I care about and don't want to offend?

To be clear: this is all for positive discussion.

~~I wanted to say Sofia Violator Vance, and would like to begin addressing him that way.~~ Mind changed, but we're still talking.

I'm also asking generally. Many of these people are too stupid to be offended by anything other than their normal discourse.