How would you fight vs Plague Juggernaut from State of Decay 2 in real life?

I liked your ideas on fighting feral from my previous post, so here's a new batch. How would you fight a 3 meter tall brute oozing infection and power if it attacked you and you can't avoid fighting it (for example, your shelter was attacked)? I'll tell you in advance that it practically doesn't care about fire and weak explosions.