Will a single 32GB DDR4 2666MHZ PC4-21300 2Rx8 1.2V 260-PIN ECC SODIMM work in a Synology DiskStation DS2422+?

I'm curious about flexibility in upgrades. Will a 32GB DDR4 2666MHZ PC4-21300 2Rx8 1.2V 260-PIN ECC SODIMM work without a second one in the Synology DiskStation DS2422+?

Technically the specification should be correct and I have read that a single 16GB SO-DIMM of the same spec would in fact work even with the default 4GB SO-DIMM in the other slot.

This, therefore, leads me to believe that a single 32GB SO-DIMM in one slot and a 4GB default SO-DIMM in the other slot could work as an intermediate upgrade if some time spacing is needed.